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Protox Therapeutics protox ii server software
Protox Ii Server Software, supplied by Protox Therapeutics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/protox-ii+software/0+3+protox+server/pm42265167-127-0-0
Average 86 stars, based on 1 article reviews
protox ii server software - by Bioz Stars, 2026-09
86/100 stars

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Article Title: Identification of novel sulfathiazole-triazolo-chalcone hybrids as VEGFR-2/EGFR dual inhibitors with antiangiogenic activity and apoptotic induction.
Article Snippet: Correspondence Amany S. Mostafa, Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.. Email: amanysalah2002@yahoo.com Abstract Certain sulfathiazole‐triazolo chalcone hybrids were identified as anticancer agents with dual vascular endothelial growth factor receptor‐2 (VEGFR‐2)/epidermal growth factor receptor (EGFR) kinase inhibitory effect.. All of the compounds were evaluated for their cytotoxic activity against the MCF‐7 and HepG‐2 tumor cell lines.

Article Title: In silico toxicity and immunological interactions of components of calcium silicate-based and epoxy resin-based endodontic sealers.
Article Snippet: Objectives The present study aimed to determine in silico toxicity predictions of test compounds from hydraulic calcium silicate-based sealers (HCSBS) and AH Plus and computationally simulate the interaction between these substances and mediators of periapical inflammation via molecular docking.. Materials and Methods All chemical information of the test compounds was obtained from the PubChem site.. Predictions for bioavailability and toxicity analyses were determined by the Molinspiration Cheminformatics, pkCSM, ProTox-II and OSIRIS Property Explorer platforms.

Article Title: Drug screening of α-amylase inhibitors as candidates for treating diabetes.
Article Snippet: Furthermore, ProTox- II software33 was used to estimate the organ toxicities and toxicological end points of molecules and their LD50 (median LD50, the amount which causes the death of 50% of a group of test animals) values.

Article Title: Biocompatible New Coumarins as Dual-Target Anti-Inflammatory Agents: Insights from Chemistry to Toxicity
Article Snippet: Salicylic acid (SA), a key metabolite of aspirin, has limited in vitro inhibition capacity toward inflammationmediated enzymes, poor oral bioavailability, and harmful side effects.. In this study, SA-derived coumarins ( P-COA and COA1 –COA6 ) were synthesized and structurally characterized via FTIR, 1 H-NMR, 13 C-NMR, and HRMS.. Their dual-inhibitory potential against COX-2/5-LOX was evaluated by assessing their ability to inhibit COX-1, COX-2, and 5-LOX, supported by molecular docking studies using three inflammation-related enzymatic models.

Software:

Article Title: Identification of novel sulfathiazole-triazolo-chalcone hybrids as VEGFR-2/EGFR dual inhibitors with antiangiogenic activity and apoptotic induction.
Article Snippet: Correspondence Amany S. Mostafa, Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.. Email: amanysalah2002@yahoo.com Abstract Certain sulfathiazole‐triazolo chalcone hybrids were identified as anticancer agents with dual vascular endothelial growth factor receptor‐2 (VEGFR‐2)/epidermal growth factor receptor (EGFR) kinase inhibitory effect.. All of the compounds were evaluated for their cytotoxic activity against the MCF‐7 and HepG‐2 tumor cell lines.

Article Title: In silico toxicity and immunological interactions of components of calcium silicate-based and epoxy resin-based endodontic sealers.
Article Snippet: Objectives The present study aimed to determine in silico toxicity predictions of test compounds from hydraulic calcium silicate-based sealers (HCSBS) and AH Plus and computationally simulate the interaction between these substances and mediators of periapical inflammation via molecular docking.. Materials and Methods All chemical information of the test compounds was obtained from the PubChem site.. Predictions for bioavailability and toxicity analyses were determined by the Molinspiration Cheminformatics, pkCSM, ProTox-II and OSIRIS Property Explorer platforms.

Article Title: Drug screening of α-amylase inhibitors as candidates for treating diabetes.
Article Snippet: Furthermore, ProTox- II software33 was used to estimate the organ toxicities and toxicological end points of molecules and their LD50 (median LD50, the amount which causes the death of 50% of a group of test animals) values.

Article Title: Biocompatible New Coumarins as Dual-Target Anti-Inflammatory Agents: Insights from Chemistry to Toxicity
Article Snippet: Salicylic acid (SA), a key metabolite of aspirin, has limited in vitro inhibition capacity toward inflammationmediated enzymes, poor oral bioavailability, and harmful side effects.. In this study, SA-derived coumarins ( P-COA and COA1 –COA6 ) were synthesized and structurally characterized via FTIR, 1 H-NMR, 13 C-NMR, and HRMS.. Their dual-inhibitory potential against COX-2/5-LOX was evaluated by assessing their ability to inhibit COX-1, COX-2, and 5-LOX, supported by molecular docking studies using three inflammation-related enzymatic models.

Comparison:

Article Title: Identification of novel sulfathiazole-triazolo-chalcone hybrids as VEGFR-2/EGFR dual inhibitors with antiangiogenic activity and apoptotic induction.
Article Snippet: Correspondence Amany S. Mostafa, Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.. Email: amanysalah2002@yahoo.com Abstract Certain sulfathiazole‐triazolo chalcone hybrids were identified as anticancer agents with dual vascular endothelial growth factor receptor‐2 (VEGFR‐2)/epidermal growth factor receptor (EGFR) kinase inhibitory effect.. All of the compounds were evaluated for their cytotoxic activity against the MCF‐7 and HepG‐2 tumor cell lines.

Article Title: In silico toxicity and immunological interactions of components of calcium silicate-based and epoxy resin-based endodontic sealers.
Article Snippet: Objectives The present study aimed to determine in silico toxicity predictions of test compounds from hydraulic calcium silicate-based sealers (HCSBS) and AH Plus and computationally simulate the interaction between these substances and mediators of periapical inflammation via molecular docking.. Materials and Methods All chemical information of the test compounds was obtained from the PubChem site.. Predictions for bioavailability and toxicity analyses were determined by the Molinspiration Cheminformatics, pkCSM, ProTox-II and OSIRIS Property Explorer platforms.

Article Title: Drug screening of α-amylase inhibitors as candidates for treating diabetes.
Article Snippet: Furthermore, ProTox- II software33 was used to estimate the organ toxicities and toxicological end points of molecules and their LD50 (median LD50, the amount which causes the death of 50% of a group of test animals) values.

Article Title: Biocompatible New Coumarins as Dual-Target Anti-Inflammatory Agents: Insights from Chemistry to Toxicity
Article Snippet: Salicylic acid (SA), a key metabolite of aspirin, has limited in vitro inhibition capacity toward inflammationmediated enzymes, poor oral bioavailability, and harmful side effects.. In this study, SA-derived coumarins ( P-COA and COA1 –COA6 ) were synthesized and structurally characterized via FTIR, 1 H-NMR, 13 C-NMR, and HRMS.. Their dual-inhibitory potential against COX-2/5-LOX was evaluated by assessing their ability to inhibit COX-1, COX-2, and 5-LOX, supported by molecular docking studies using three inflammation-related enzymatic models.

Control:

Article Title: Identification of novel sulfathiazole-triazolo-chalcone hybrids as VEGFR-2/EGFR dual inhibitors with antiangiogenic activity and apoptotic induction.
Article Snippet: Correspondence Amany S. Mostafa, Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.. Email: amanysalah2002@yahoo.com Abstract Certain sulfathiazole‐triazolo chalcone hybrids were identified as anticancer agents with dual vascular endothelial growth factor receptor‐2 (VEGFR‐2)/epidermal growth factor receptor (EGFR) kinase inhibitory effect.. All of the compounds were evaluated for their cytotoxic activity against the MCF‐7 and HepG‐2 tumor cell lines.

Article Title: In silico toxicity and immunological interactions of components of calcium silicate-based and epoxy resin-based endodontic sealers.
Article Snippet: Objectives The present study aimed to determine in silico toxicity predictions of test compounds from hydraulic calcium silicate-based sealers (HCSBS) and AH Plus and computationally simulate the interaction between these substances and mediators of periapical inflammation via molecular docking.. Materials and Methods All chemical information of the test compounds was obtained from the PubChem site.. Predictions for bioavailability and toxicity analyses were determined by the Molinspiration Cheminformatics, pkCSM, ProTox-II and OSIRIS Property Explorer platforms.

Article Title: Drug screening of α-amylase inhibitors as candidates for treating diabetes.
Article Snippet: Furthermore, ProTox- II software33 was used to estimate the organ toxicities and toxicological end points of molecules and their LD50 (median LD50, the amount which causes the death of 50% of a group of test animals) values.

Article Title: Biocompatible New Coumarins as Dual-Target Anti-Inflammatory Agents: Insights from Chemistry to Toxicity
Article Snippet: Salicylic acid (SA), a key metabolite of aspirin, has limited in vitro inhibition capacity toward inflammationmediated enzymes, poor oral bioavailability, and harmful side effects.. In this study, SA-derived coumarins ( P-COA and COA1 –COA6 ) were synthesized and structurally characterized via FTIR, 1 H-NMR, 13 C-NMR, and HRMS.. Their dual-inhibitory potential against COX-2/5-LOX was evaluated by assessing their ability to inhibit COX-1, COX-2, and 5-LOX, supported by molecular docking studies using three inflammation-related enzymatic models.



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